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Article

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

23 Oct 1998

Abstract excerpt

Recently exonic and intronic mutations in the gene for microtubule-associated protein tau have been discovered in cases of familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Intronic mutations have been shown to lead to an abnormal preponderance of four-repeat tau isoforms. The effects of the exonic mutations are unknown. We report here that the G272V, P301L, V337M and R406W...

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Identifiers

PMID: 9824291
DOI: 10.1016/s0014-5793(98)01217-4

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Related research

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Research trail→

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Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assemblyPMID 9824291Read ↗

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10Semantic proximity Read ↗

FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific FashionSemantic proximity Read ↗

Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).Semantic proximity Read ↗

Functional effects of tau gene mutations ΔN296 and N296HSemantic proximity Read ↗

Tau gene mutations: dissecting the pathogenesis of FTDP-17.Semantic proximity Read ↗

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutationsSemantic proximity Read ↗

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).Semantic proximity Read ↗

FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells.Semantic proximity Read ↗

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.Semantic proximity Read ↗

FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions.Semantic proximity Read ↗

Missense tau mutations identified in FTDP-17 have a small effect on tau–microtubule interactionsSemantic proximity Read ↗

Frontotemporal dementia and parkinsonism linked to chromosome 17.Semantic proximity Read ↗

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