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Article

Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Panda Dulal, Samuel Jonathan C, Massie Michelle, Feinstein Stuart C, Wilson Leslie

Abstract excerpt

The microtubule (MT)-associated protein tau is important in neuronal development and in Alzheimer's and other neurodegenerative diseases. Genetic analyses have established a cause-and-effect relationship between tau dysfunction/misregulation and neuronal cell death and dementia in frontotemporal dementia and parkinsonism associated with chromosome 17; several mutations causing this dementia lead to increased...

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Identifiers

PMID: 12886013
DOI: 10.1073/pnas.1633508100
PMCID: PMC170955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease.PMID 12886013Read ↗

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