Article

Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer’s disease

2026-01-22

Abstract excerpt

Alzheimer’s disease (AD) is increasingly associated with early circuit dysfunction preceding cognitive decline, including neuronal hyperactivity and neuropsychiatric symptoms linked to mesolimbic pathways. The nucleus accumbens (nAc), a central regulator of reward and motivational processing, exhibits early alterations in excitation/inhibition balance in patients and experimental models; however, the synaptic mech...

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Literature Corpus work: 75762928-a168-5a22-a0b7-60074152ab43
DOI: 10.64898/2026.01.19.700385

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Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer’s diseaseDOI 10.64898/2026.01.19.700385Read

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