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Article

The implication of AMPA receptor in synaptic plasticity impairment and intellectual disability in fragile X syndrome.

Physiological research - 24 Nov 2017

Cheng Gui-Rong, Li Xiang-Yu, Xiang Ya-Die, Liu Dan, McClintock Shawn M, Zeng Yan

Abstract excerpt

Fragile X syndrome (FXS) is the most frequently inherited form of intellectual disability and prevalent single-gene cause of autism. A priority of FXS research is to determine the molecular mechanisms underlying the cognitive and social functioning impairments in humans and the FXS mouse model. Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28730825
DOI: 10.33549/physiolres.933473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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