Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.

doi:10.1210/jc.2005-2056

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Article

Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.

The Journal of clinical endocrinology and metabolism - 1 May 2006

Hinney Anke, Bettecken Thomas, Tarnow Patrick, Brumm Harald, Reichwald Kathrin, Lichtner Peter, Scherag André, Nguyen Thuy Trang, Schlumberger Pia, Rief Winfried, Vollmert Caren, Illig Thomas, Wichmann H-Erich, Schäfer Helmut, Platzer Matthias, Biebermann Heike, Meitinger Thomas, Hebebrand Johannes

Abstract excerpt

CONTEXT: Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals. OBJECTIVE: Our objective was to assess the relevance of MC4R mutations in a German population-based sample. DESIGN AND SETTING: We conducted a mutation screen of the MC4R gene by capillary...

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PMID: 16492696
DOI: 10.1210/jc.2005-2056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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