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Article

Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

Circulation - 28 Feb 2006

Grube Markus, Meyer zu Schwabedissen Henriette E U, Präger Damaris, Haney Jeanette, Möritz Klaus-Uwe, Meissner Konrad, Rosskopf Dieter, Eckel Lothar, Böhm Michael, Jedlitschky Gabriele, Kroemer Heyo K

Abstract excerpt

BACKGROUND: To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN2 in the human heart, uptake of drugs by OCTN2, and functional coupling of OCTN2 with the...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Solute Carrier Family 22 Member 5

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Source

Identifiers

PMID: 16490820
DOI: 10.1161/CIRCULATIONAHA.105.586107

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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