Article
Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine.
Scientific reports - 16 Feb 2017
Hooker Jacob M, Strebl Martin G, Schroeder Frederick A, Wey Hsiao-Ying, Ambardekar Amrut V, McKinsey Timothy A, Schoenberger Matthias
Abstract excerpt
The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a single isoform of voltage gated sodium channels - SCN5A. However, linking changes in SCN5A expression levels to human disease in vivo has not yet been possible. Radiocaine, an F-18 radiotracer for positron emission tomography (PET), is the...
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