Article
Association of TLR4 single-nucleotide polymorphisms and sarcoidosis in Greek patients.
Genetic testing and molecular biomarkers - 1 Dec 2009
Iliadi Alexandra, Makrythanasis Periklis, Tzetis Maria, Tsipi Maria, Traeger-Synodinos Jan, Ioannou Penelope C, Rapti Aggeliki, Kanavakis Emmanuel, Christopoulos Theodore K
Abstract excerpt
The present study investigates the potential role of Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile single-nucleotide polymorphisms (SNPs) as risk factors in the development of sarcoidosis using a novel high-throughput microtiter well-based bioluminometric genotyping assay. One hundred and nineteen Greek patients with sarcoidosis and 209 control subjects were genotyped for the two SNPs of the TLR4 gene. The...
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