Article
Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.
QJM : monthly journal of the Association of Physicians - 1 Apr 2018
Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer D N, Kunkel S L, Knaus U G, Shields D C, Moller D R, Bowie A G, Fallon P G, Hogaboam C M, Armstrong M E, Donnelly S C
Abstract excerpt
BACKGROUND/INTRODUCTION: Sarcoidosis is a multi-systemic disorder of unknown etiology, characterized by the presence of non-caseating granulomas in target organs. In 90% of cases, there is thoracic involvement. Fifty to seventy percent of pulmonary sarcoidosis patients will experience acute, self-limiting disease. For the subgroup of patients who develop persistent disease, no targeted therapy is currently...
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