Article
Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease.
Aging clinical and experimental research - 1 Dec 2005
Ventriglia Mariacarla, Bocchio Chiavetto Luisella, Scassellati Catia, Squitti Rosanna, Binetti Giuliano, Ghidoni Roberta, Rossini Paolo Maria, Gennarelli Massimo
Abstract excerpt
BACKGROUND AND AIMS: Substantial evidence supports the hypothesis that impairment of mitochondrial function and increased oxidative damage are involved in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease (AD). Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen...
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