Article
No association between Ala9Val functional polymorphism of MnSOD gene and schizophrenia in a representative Italian sample.
Neuroscience letters - 27 Dec 2006
Ventriglia Mariacarla, Scassellati Catia, Bonvicini Cristian, Squitti Rosanna, Bevacqua Maria Gabriela, Foresti Giovanni, Tura Gian Battista, Gennarelli Massimo
Abstract excerpt
Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The polymorphisms in the genes encoding antioxidant enzymes, such as manganese superoxide dismutase (MnSOD) should, thus, result in predisposition to this psychiatric disorder. A functional amino acid polymorphism (Ala9Val) has been described in the signal sequence of enzyme associated with a decreased...
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