Article
Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Jan 2005
Akyol Omer, Yanik Medaim, Elyas Halit, Namli Mustafa, Canatan Halit, Akin Haluk, Yuce Huseyin, Yilmaz H Ramazan, Tutkun Hamdi, Sogut Sadik, Herken Hasan, Ozyurt Hüseyin, Savas Haluk Asuman, Zoroglu Suleyman Salih
Abstract excerpt
Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Polymorphisms in the genes encoding antioxidant enzymes should...
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