Article
Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli.
Journal of bacteriology - 1 Jul 1991
Greenberg J T, Chou J H, Monach P A, Demple B
Abstract excerpt
Exposure of Escherichia coli to superoxide-generating drugs, such as menadione or paraquat, uniquely induces approximately 40 proteins, nine of which are under the positive control of the soxR locus (at min 92). We report here that certain mutations at a separate locus that we have named soxQ (at min 34) confer some of the phenotypes seen in soxR-constitutive strains, including resistance to menadione. A...
Topics
- Anti-Bacterial Agents
- Crosses, Genetic
- DNA Transposable Elements
- Drug Resistance, Microbial
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genotype
- Glucosephosphate Dehydrogenase
- Mutagenesis