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Article

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.

The EMBO journal - 1 May 1998

Hidalgo E, Leautaud V, Demple B

Abstract excerpt

The SoxR protein of Escherichia coli responds to redox signals by activating the transcription of soxS, which encodes another transcription activator that directly stimulates oxidative stress genes. We show here that transcription of the soxR gene, which is positioned head-to-head with soxS in the chromosome, initiates in the intergenic region and is itself repressed by SoxR protein in in vitro transcription...

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Identifiers

PMID: 9564045
DOI: 10.1093/emboj/17.9.2629
PMCID: PMC1170604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.PMID 9564045Read ↗

Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.Semantic proximity Read ↗

Novel protein--protein interaction between Escherichia coli SoxS and the DNA binding determinant of the RNA polymerase alpha subunit: SoxS functions as a co-sigma factor and redeploys RNA polymerase from UP-element-containing promoters to SoxS-dependent promoters during oxidative stress.Semantic proximity Read ↗

Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.Semantic proximity Read ↗

Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form.Semantic proximity Read ↗

Differential activities of the SoxR protein of Escherichia coli: SoxS is not required for gene activation under iron deprivation.Semantic proximity Read ↗

A comprehensive alanine scanning mutagenesis of the Escherichia coli transcriptional activator SoxS: identifying amino acids important for DNA binding and transcription activation.Semantic proximity Read ↗

Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli.Semantic proximity Read ↗

A reducing system of the superoxide sensor SoxR in Escherichia coli.Semantic proximity Read ↗

A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator.Semantic proximity Read ↗

Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S centers of SoxR in vivo.Semantic proximity Read ↗

Proteolytic degradation of Escherichia coli transcription activators SoxS and MarA as the mechanism for reversing the induction of the superoxide (SoxRS) and multiple antibiotic resistance (Mar) regulons.Semantic proximity Read ↗

Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.Semantic proximity Read ↗

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