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Article

Nitrofurantoin, phenazopyridine, and the superoxide-response regulon soxRS of Escherichia coli.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Dec 2013

Amábile-Cuevas Carlos F, Arredondo-García José Luis

Abstract excerpt

Nitrofurantoin and phenazopyridine are two drugs commonly used against urinary tract infections. Both compounds exert oxidative damage in patients deficient in glucose-6-phosphate dehydrogenase. This study was done to assess the interactions of these drugs with the soxRS regulon of Escherichia coli, a superoxide-defense system (that includes a nitroreductase that yields the active metabolite of nitrofurantoin)...

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PMID: 23793794
DOI: 10.1007/s10156-013-0635-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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