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Article

Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli.

Journal of bacteriology - 1 Jun 1992

Wu J, Weiss B

Abstract excerpt

soxR and soxS are adjacent genes that govern a superoxide response regulon. Previous studies revealed that induction of the regulon is accompanied by increased transcription of soxS, which can activate the target genes. Therefore, induction may occur in two stages: the soxR-dependent activation of soxS, followed by the soxS-dependent induction of other genes. However, the requirement for soxR was unproven because...

Topics

Bacterial Proteins
Cloning, Molecular
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genetic Complementation Test
Mutation
Paraquat
Plasmids
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Superoxides

Trans-Activators

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 1317841
DOI: 10.1128/jb.174.12.3915-3920.1992
PMCID: PMC206099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1317841-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli.PMID 1317841Read ↗

A reducing system of the superoxide sensor SoxR in Escherichia coli.Semantic proximity Read ↗

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12.Semantic proximity Read ↗

Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.Semantic proximity Read ↗

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.Semantic proximity Read ↗

Genetic evidence for pre-recruitment as the mechanism of transcription activation by SoxS of Escherichia coli: the dominance of DNA binding mutations of SoxS.Semantic proximity Read ↗

A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium).Semantic proximity Read ↗

Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.Semantic proximity Read ↗

A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator.Semantic proximity Read ↗

Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.Semantic proximity Read ↗

Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli.Semantic proximity Read ↗

Differential activities of the SoxR protein of Escherichia coli: SoxS is not required for gene activation under iron deprivation.Semantic proximity Read ↗

Proteolytic degradation of Escherichia coli transcription activators SoxS and MarA as the mechanism for reversing the induction of the superoxide (SoxRS) and multiple antibiotic resistance (Mar) regulons.Semantic proximity Read ↗

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