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Article

Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.

Journal of bacteriology - 1 Apr 2003

Chander Monica, Raducha-Grace Laura, Demple Bruce

Abstract excerpt

The soxRS regulon protects Escherichia coli from superoxide and nitric oxide stress. SoxR protein, a transcription factor that senses oxidative stress via its [2Fe-2S] centers, transduces the signal to the soxS promoter to stimulate RNA polymerase. Here we describe 29 mutant alleles of soxR that cause defects in the activation of soxS transcription in response to paraquat, a superoxide stress agent. Owing to the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12670967
DOI: 10.1128/JB.185.8.2441-2450.2003
PMCID: PMC152623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.PMID 12670967Read ↗

Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.Semantic proximity Read ↗

Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.Semantic proximity Read ↗

Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form.Semantic proximity Read ↗

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.Semantic proximity Read ↗

A reducing system of the superoxide sensor SoxR in Escherichia coli.Semantic proximity Read ↗

Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli.Semantic proximity Read ↗

A comprehensive alanine scanning mutagenesis of the Escherichia coli transcriptional activator SoxS: identifying amino acids important for DNA binding and transcription activation.Semantic proximity Read ↗

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12.Semantic proximity Read ↗

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Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli.Semantic proximity Read ↗

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