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Article

The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

The EMBO journal - 1 Aug 1991

Simon M, Giot L, Faye G

Abstract excerpt

In Saccharomyces cerevisiae, DNA polymerase delta (POLIII), the product of the CDC2 (POL3) gene, possesses, in its N-terminal half, the well conserved 3-domain 3' to 5' exonuclease site. Strains selectively mutagenized in this site display a mutator phenotype detected as a drastically increased spontaneous forward mutation rate to canavanine resistance or as an elevated reversion rate to lysine prototrophy....

Topics

Amino Acid Sequence
DNA Polymerase III
DNA Replication
DNA, Fungal
DNA-Directed DNA Polymerase
Exonucleases
Genes, Fungal
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Saccharomyces cerevisiae

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Identifiers

PMID: 1648480
DOI: 10.1002/j.1460-2075.1991.tb07751.x
PMCID: PMC452904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1648480-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.PMID 1648480Read ↗

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