Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.

doi:10.1038/369565a0

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Article

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.

Nature - 16 Jun 1994

Lok S, Kaushansky K, Holly R D, Kuijper J L, Lofton-Day C E, Oort P J, Grant F J, Heipel M D, Burkhead S K, Kramer J M

Abstract excerpt

The major regulator of circulating platelet levels is believed to be a cytokine termed thrombopoietin. It is thought to be a lineage-specific cytokine affecting the proliferation and maturation of committed cells resulting in the production of megakaryocytes and platelets. Despite considerable ef...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blood Platelets
Cell Differentiation
Cell Line
Cloning, Molecular
Cricetinae
DNA, Complementary
Erythropoietin
Humans
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Neoplasm Proteins

Protein Sorting Signals

Source

Open in PubMed

Identifiers

PMID: 8202158
DOI: 10.1038/369565a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8202158-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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