Article
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.
Nature - 16 Jun 1994
Lok S, Kaushansky K, Holly R D, Kuijper J L, Lofton-Day C E, Oort P J, Grant F J, Heipel M D, Burkhead S K, Kramer J M
Abstract excerpt
The major regulator of circulating platelet levels is believed to be a cytokine termed thrombopoietin. It is thought to be a lineage-specific cytokine affecting the proliferation and maturation of committed cells resulting in the production of megakaryocytes and platelets. Despite considerable efforts by a number of laboratories, the unequivocal identification of thrombopoietin has proven elusive. Here we report...
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