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Article

Neuronal activity-dependent cell survival mediated by transcription factor MEF2.

Science (New York, N.Y.) - 22 Oct 1999

Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg M E

Abstract excerpt

During mammalian development, electrical activity promotes the calcium-dependent survival of neurons that have made appropriate synaptic connections. However, the mechanisms by which calcium mediates neuronal survival during development are not well characterized. A transcription-dependent mechanism was identified by which calcium influx into neurons promoted cell survival. The transcription factor MEF2 was...

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Identifiers

PMID: 10531066
DOI: 10.1126/science.286.5440.785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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