Article
Apoptosis induced by neoadjuvant chemotherapy in breast cancer.
Pathology - 1 Feb 2006
Tiezzi Daniel Guimarães, De Andrade Jurandyr Moreira, Cândido dos Reis Francisco José, Marana Heitor Ricardo Cosiski, Ribeiro-Silva Alfredo, Tiezzi Marcelo Guimarães, Pereira Antônio Plácido
Abstract excerpt
AIM: To evaluate the relationship between apoptosis induced by chemotherapy and clinical response in breast cancer. METHODS: Apoptosis index (AI), mutant p53 and Bcl-2 protein expression were evaluated in 44 breast tumour samples from patients submitted to neoadjuvant chemotherapy. Objective response (OR) to primary chemotherapy was observed in 37 patients (84%) and no response (NR) in seven. AI was measured by...
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