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Article

Synthesis of Bcl-2 in response to anthracycline treatment may contribute to an apoptosis-resistant phenotype in leukemic cell lines.

Cytometry - 1 Jun 1999

Durrieu F, Belaud-Rotureau M A, Lacombe F, Dumain P, Reiffers J, Boisseau M R, Bernard P, Belloc F

Abstract excerpt

BACKGROUND: Some forms of chemoresistance in leukemia may start from failure of tumour cells to successfully undergo apoptosis and Bcl-2 may play a role in this defect. Therefore, we evaluated the Bcl-2 content and synthesis in relation with the apoptotic potential in leukemic cell lines after anthracycline treatment. METHODS: U937, HL60, and K562 cells and their drug resistant (DR) variants were treated with...

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Identifiers

PMID: 10554162
DOI: 10.1002/(sici)1097-0320(19990601)36:2<140::aid-cyto8>3.0.co;2-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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