Expression of the <i>bcl</i>‐2 gene family in normal and malignant breast tissue: Low <i>bax</i>‐α expression in tumor cells correlates with resistance towards apoptosis

Abstract excerpt

We have studied the expression of the apoptosis-regulating genes bcl-2, bcl-x, bax and APO-1/fas (CD95) in human breast cancer. The expression pattern of these genes in human breast-cancer tissues and breast-cancer-derived cell lines was compared to that seen in normal breast epithelium and breast epithelial cell lines. No difference with regard to bcl-2 and bcl-xL expression was observed between normal breast...

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