Article
An utter refutation of the "fundamental theorem of the HapMap".
European journal of human genetics : EJHG - 1 Apr 2006
Terwilliger Joseph D, Hiekkalinna Tero
Abstract excerpt
The International HapMap Project was proposed in order to quantify linkage disequilibrium (LD) relationships among human DNA polymorphisms in an assortment of populations, in order to facilitate the process of selecting a minimal set of markers that could capture most of the signal from the untyped markers in a genome-wide association study. The central dogma can be summarized by the argument that if a marker is...
Topics
- Chromosome Mapping
- Haplotypes
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- Sample Size
- Selection Bias