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Article

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).

Blood - 15 Jun 2006

Persidsky Yuri, Heilman David, Haorah James, Zelivyanskaya Marina, Persidsky Raisa, Weber Gregory A, Shimokawa Hiroaki, Kaibuchi Kozo, Ikezu Tsuneya

Abstract excerpt

The blood-brain barrier (BBB) is compromised during progressive HIV-1 infection, but how this occurs is incompletely understood. We studied the integrity of tight junctions (TJs) of brain microvascular endothelial cells (BMVECs) in an in vitro BBB system and in human brain tissues with HIV-1 encephalitis (HIVE). A downregulation of TJ proteins, claudin-5 and occludin, paralleled monocyte migration into the brain...

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Source

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Identifiers

PMID: 16478881
DOI: 10.1182/blood-2005-11-4721
PMCID: PMC1895810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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