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Article

Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability.

The Journal of biological chemistry - 31 Mar 2006

Stamatovic Svetlana M, Dimitrijevic Oliver B, Keep Richard F, Andjelkovic Anuska V

Abstract excerpt

Monocyte chemoattractant protein-1 (MCP-1 or CCL2) regulates blood-brain barrier permeability by inducing morphological and biochemical alterations in the tight junction (TJ) complex between brain endothelial cells. The present study used cultured brain endothelial cells to examine the signaling networks involved in the redistribution of TJ proteins (occludin, ZO-1, ZO-2, claudin-5) by CCL2. The CCL2-induced...

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Identifiers

PMID: 16439355
DOI: 10.1074/jbc.M513122200

Genes

CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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