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Article

Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2002

Adamson Peter, Wilbourn Barry, Etienne-Manneville Sandrine, Calder Virginia, Beraud Evelyne, Milligan Graeme, Couraud Pierre-Olivier, Greenwood John

Abstract excerpt

We have previously shown that the engagement of ICAM-1 on brain endothelial cells (EC) results in the propagation of EC signaling pathways that are necessary for efficient lymphocyte migration across the tight vascular barriers of the brain. Signaling via this receptor alone, however, is unlikely to explain the differential recruitment of leukocytes at different vascular beds. In this study, we investigated the...

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PMID: 12153986
DOI: 10.1096/fj.02-0035com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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