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Article

Aberrant T cell migration toward RANTES and MIP-1alpha in patients with multiple sclerosis: Overexpression of chemokine receptor CCR5

1 Sept 2000

Abstract excerpt

Trafficking of inflammatory T cells into the central nervous system (CNS) plays an important role in the pathogenesis of multiple sclerosis. The directional migratory ability of peripheral T cells is associated with interactions of chemokines with their receptors expressed on T cells. In this study, transmigration of peripheral T cells toward a panel of chemokines was examined in patients with multiple sclerosis...

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PMID: 10960051
DOI: 10.1093/brain/123.9.1874

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