Article

Zika virus E protein alters blood-brain barrier by modulating brain microvascular endothelial cell and astrocyte functions

2023-02-10

Abstract excerpt

Neurotropic viruses can cross the otherwise dynamically regulated blood-brain barrier (BBB) and affect the brain cells. Zika virus (ZIKV) is an enveloped neurotropic Flavivirus known to cause severe neurological complications, such as encephalitis and foetal microcephaly. In the present study, we used human brain microvascular endothelial cells (hBMECs) and human progenitor derived astrocytes to form a physiologi...

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Literature Corpus work: 40e725cc-099a-55c0-8381-38e11acbf5b0
DOI: 10.1101/2023.02.09.527854

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