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Article

HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2014

Tan Suiyi, Duan Heng, Xun Tianrong, Ci Wei, Qiu Jiayin, Yu Fei, Zhao Xuyan, Wu Linxuan, Li Lin, Lu Lu, Jiang Shibo, Liu Shuwen

Abstract excerpt

The breakdown of human retinal pigment epithelial (HRPE) barrier is considered as the etiology of retinopathy, which affects the quality of life of HIV/AIDS patients. Here we demonstrate that HIV-1 could directly impair HRPE barrier function, which leads to the translocation of HIV-1 and bacteria...

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Source

Identifiers

PMID: 24840331
DOI: 10.1038/labinvest.2014.72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24840331-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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