Article
Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior.
Psychopharmacology - 1 Jan 1992
Weerts E M, Miller L G, Hood K E, Miczek K A
Abstract excerpt
Selective breeding for aggressive behavior alters GABA-dependent chloride uptake and behavioral response to benzodiazepine treatment. Pharmacological and biochemical studies examined subjects from three lines of adult male ICR mice selectively bred for either high levels or low levels of aggressive behavior, as well as unselected controls. Selective breeding produced two lines of behaviorally distinct males....
Topics
- Aggression
- Animals
- Chlorides
- Flumazenil
- Genetics, Behavioral
- Male
- Mice
- Mice, Inbred ICR
- Phenotype
- Receptors, GABA-A
- gamma-Aminobutyric Acid