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Article

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.

Human molecular genetics - 15 Mar 2012

Yu Wendou, Polepalli Jai, Wagh Dhananjay, Rajadas Jayakumar, Malenka Robert, Lu Bingwei

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia in the elderly. Accumulating evidence supports soluble amyloid-β (Aβ) oligomers as the leading candidate for the causative agent in AD and synapses as the primary site of Aβ oligomer action. However, the molecular and cellular mechanisms by which Aβ oligomers cause synaptic dysfunction and cognitive impairments...

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Source

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Identifiers

PMID: 22156579
DOI: 10.1093/hmg/ddr576
PMCID: PMC3284124

Genes

MARK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.PMID 22156579Read ↗

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