Article
The X chromosome deletion in HYP mice extends into the intergenic region but does not include the SAT gene downstream from Phex.
Cytogenetic and genome research - 1 Jan 2002
Sabbagh Y, Gauthier C, Tenenhouse H S
Abstract excerpt
The murine Hyp mutation is a model for X-linked hypophosphatemia (XLH), the most prevalent form of inherited rickets in humans. Although mutations in the murine Phex gene and the human PHEX gene have been identified in both murine and human disorders, the extent of the Hyp deletion on the mouse X chromosome has not been delineated. In the present study we demonstrate that the Hyp deletion starts in the middle of...
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