Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

Cancer research - 1 May 2008

Anzo Makoto, Cobb Laura J, Hwang David L, Mehta Hemal, Said Jonathan W, Yakar Shoshana, LeRoith Derek, Cohen Pinchas

Abstract excerpt

The role of systemic and local insulin-like growth factor I (IGF-I) in the development of prostate cancer is still controversial. Transgenic adenocarcinoma mouse prostate (TRAMP) mice express the SV40 T-antigen under the control of the probasin promoter, and spontaneously develop prostate cancer. We crossed TRAMP mice with liver IGF-deficient (LID) mice to produce LID-TRAMP mice, a mouse model of prostate cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Growth Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Insulin-Like Growth Factor I

Share to Neoplasm Metastasis

Share to Prostatic Neoplasms

Share to Tumor Burden

Source

Open in PubMed Open full text

Identifiers

PMID: 18451161
DOI: 10.1158/0008-5472.CAN-07-3165
PMCID: PMC2928555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.PMID 18451161Read ↗

Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.Semantic proximity Read ↗

The insulin-like growth factor (IGF) axis as an anticancer target in prostate cancer.Semantic proximity Read ↗

Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms.Semantic proximity Read ↗

A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model.Semantic proximity Read ↗

Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat.Semantic proximity Read ↗

Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP mice.Semantic proximity Read ↗

Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype.Semantic proximity Read ↗

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth<sup>1</sup>Semantic proximity Read ↗

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapySemantic proximity Read ↗

Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice.Semantic proximity Read ↗

The role of insulin-like growth factor-II in cancer growth and progression evidenced by the use of ribozymes and prostate cancer progression models.Semantic proximity Read ↗

Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.