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Article

IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms.

Cancer biology & therapy - 1 Apr 2007

Takaoka Munenori, Kim Seok-Hyun, Okawa Takaomi, Michaylira Carmen Z, Stairs Douglas B, Johnstone Cameron N, Andl Claudia D, Rhoades Ben, Lee James J, Klein-Szanto Andres J P, El-Deiry Wafik S, Nakagawa Hiroshi

Abstract excerpt

Insulin-like growth factor binding protein (IGFBP)-3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. IGFBP-3 is overexpressed frequently in esophageal cancer. Yet, the role of IGFBP-3 in esophageal tumor biology remains elusive. To delineate the functional consequences of IGFBP-3 overexpression, we stably transduced Ha-Ras(V12)-transformed human esophageal cells with...

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Identifiers

PMID: 17457048
DOI: 10.4161/cbt.6.4.3832
PMCID: PMC2993006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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