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Article

IGFBP-3 is a metastasis suppression gene in prostate cancer.

Cancer research - 1 Aug 2011

Mehta Hemal H, Gao Qinglei, Galet Colette, Paharkova Vladislava, Wan Junxiang, Said Jonathan, Sohn Joanne J, Lawson Gregory, Cohen Pinchas, Cobb Laura J, Lee Kuk-Wha

Abstract excerpt

The insulin-like growth factor binding protein IGFBP-3 is a proapoptotic and antiangiogenic protein in prostate cancer (CaP). Epidemiologic studies suggest that low IGFBP-3 is associated with greater risk of aggressive, metastatic prostate cancers, but in vivo functional data are lacking. Here we show that mice that are genetically deficient in IGFBP-3 exhibit weaker growth of primary prostate tumors but higher...

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Identifiers

PMID: 21697285
DOI: 10.1158/0008-5472.CAN-10-4513
PMCID: PMC3148406

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