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Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3.

Endocrinology - 1 May 2006

Oufattole Mohammed, Lin Sally Wan-Jung, Liu Bingrong, Mascarenhas Desmond, Cohen Pinchas, Rodgers Buel D

Abstract excerpt

IGF-binding protein (IGFBP)-3 has intrinsic antiproliferative and proapoptotic functions that are independent of IGF binding and may involve nuclear localization. We determined that exogenous IGFBP-3 rapidly translocates to myoblast nuclei and that a 22-residue peptide containing the metal binding domain (MBD) and nuclear localization sequence (NLS) can similarly direct chimeric GFP into myoblast nuclei....

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Identifiers

PMID: 16455777
DOI: 10.1210/en.2005-1269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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