Article
cAMP and cAMP-dependent protein kinase regulate the human heat shock protein 70 gene promoter activity.
The Journal of biological chemistry - 25 Jun 1991
Choi H S, Li B, Lin Z, Huang E, Liu A Y
Abstract excerpt
The theme of this study is an evaluation of the involvement of cAMP and cAMP-dependent protein kinase (PKA) in the regulation of the human heat shock protein (hsp) 70 gene promoter. Expression of a highly specific protein inhibitor of PKA (pRSVPKI) inhibited the basal as well as heat- and cadmium...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Autoradiography
- Bucladesine
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Colforsin
- Cyclic AMP
- DNA
- Gene Expression Regulation, Enzymologic
- Genetic Vectors
- Heat-Shock Proteins
- Humans
- Lung
- Mutation
- Promoter Regions, Genetic
- Protein Kinase Inhibitors
- Protein Kinases
- Transfection