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Article

Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.

Protein science : a publication of the Protein Society - 1 Aug 2005

Jacobs Steven A, Podell Elaine R, Wuttke Deborah S, Cech Thomas R

Abstract excerpt

Telomerase is a ribonucleoprotein complex responsible for extending the ends of eukaryotic chromosomes. Structural and biophysical studies of this enzyme have been limited by the inability to produce large amounts of recombinant protein. Here we perform a high-throughput screen to map regions of the Tetrahymena thermophila TERT (Telomerase Reverse Transcriptase) protein that are overexpressed in a soluble form in...

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Identifiers

PMID: 16046627
DOI: 10.1110/ps.051532105
PMCID: PMC2279316

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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