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Article

Phenotyping hepatitis B virus variants: from transfection towards a small animal in vivo infection model.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2005

Nassal Michael, Dallmeier Kai, Schultz Ursula, Sun Dianxing

Abstract excerpt

The existence of vaccine escape and drug resistant hepatitis B virus (HBV) variants is now well established, and various of the underlying prototypic mutations have been defined. Genotypic detection of such variants allows to predict their clinical phenotype. However, the relevance of non-predefined mutations occurring during therapy can be assessed only by phenotypic assays. The fundamental properties of a...

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PMID: 16461231
DOI: 10.1016/s1386-6532(05)80017-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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