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Article

In Vivo Modelling of Hepatitis B Virus Subgenotype A1 Replication Using Adeno-Associated Viral Vectors.

Viruses - 9 Nov 2021

Limani Shonisani Wendy, Mnyandu Njabulo, Ely Abdullah, Wadee Reubina, Kramvis Anna, Arbuthnot Patrick, Maepa Mohube Betty

Abstract excerpt

The paucity of animal models that simulate the replication of the hepatitis B virus (HBV) is an impediment to advancing new anti-viral treatments. The work reported here employed recombinant adeno-associated viruses (AAVs) to model HBV subgenotype A1 and subgenotype D3 replication in vitro and in vivo. Infection with subgenotype A1 is endemic to parts of sub-Saharan Africa, and it is associated with a high risk...

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Source

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Identifiers

PMID: 34835053
DOI: 10.3390/v13112247
PMCID: PMC8618177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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