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Article

K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.

Carcinogenesis - 1 Apr 2003

Brink Mirian, de Goeij Anton F P M, Weijenberg Matty P, Roemen Guido M J M, Lentjes Marjolein H F M, Pachen Marco M M, Smits Kim M, de Bruïne Adriaan P, Goldbohm R Alexandra, van den Brandt Piet A

Abstract excerpt

Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being mutated in 30-60% of the adenocarcinomas. In this study, 737 incident colorectal cancer (CRC) patients, originating from 120 852 men and women (55-69 years at baseline) participating in the Netherlands Cohort Study (NLCS), were studied in order to evaluate subgroups with respect to K-ras mutation status. Mutation analysis of the...

Topics

Base Sequence
Cohort Studies
Colorectal Neoplasms
DNA Primers
Genes, ras
Humans
Mutation
Netherlands

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12727799
DOI: 10.1093/carcin/bgg009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12727799-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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