Article
Expression profiling of uniparental mouse embryos is inefficient in identifying novel imprinted genes.
Genomics - 1 Apr 2006
Ruf Nico, Dünzinger Ulrich, Brinckmann Anja, Haaf Thomas, Nürnberg Peter, Zechner Ulrich
Abstract excerpt
Imprinted genes are expressed from only one allele in a parent-of-origin-specific manner. We here describe a systematic approach to identify novel imprinted genes using quantification of allele-specific expression by Pyrosequencing, a highly accurate method to detect allele-specific expression differences. Sixty-eight candidate imprinted transcripts mapping to known imprinted chromosomal regions were selected...
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