Article
Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions.
eLife - 14 Mar 2023
Edwards Carol A, Watkinson William M D, Telerman Stephanie B, Hulsmann Lisa C, Hamilton Russell S, Ferguson-Smith Anne C
Abstract excerpt
In mouse and human, genes subjected to genomic imprinting have been shown to function in development, behavior, and post-natal adaptations. Failure to correctly imprint genes in human is associated with developmental syndromes, adaptive, and metabolic disorders during life as well as numerous forms of cancer. In recent years researchers have turned to RNA-seq technologies applied to reciprocal hybrid strains of...
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