Prions, protein homeostasis, and phenotypic diversity.

doi:10.1016/j.tcb.2009.12.003

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Article

Prions, protein homeostasis, and phenotypic diversity.

Trends in cell biology - 1 Mar 2010

Halfmann Randal, Alberti Simon, Lindquist Susan

Abstract excerpt

Prions are fascinating but often misunderstood protein aggregation phenomena. The traditional association of the mammalian prion protein with disease has overshadowed a potentially more interesting attribute of prions: their ability to create protein-based molecular memories. In fungi, prions alter the relationship between genotype and phenotype in a heritable way that diversifies clonal populations. Recent...

Topics

Epigenesis, Genetic
Gene Expression Regulation, Fungal
Glutathione Peroxidase
Homeostasis
Phenotype
Prions
Protein Conformation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 20071174
DOI: 10.1016/j.tcb.2009.12.003
PMCID: PMC2846750

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