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Article

CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.

Scandinavian journal of urology and nephrology - 1 Jan 2006

Wagenius M, Borg A, Johansson L, Giwercman A, Bratt O

Abstract excerpt

OBJECTIVE: CHEK2*1100delC is a frame-shifting germ-line mutation which abolishes the function of cell-cycle-checkpoint kinase 2 (chk2) and hence impairs the cells' response to DNA damage. This variant occurs in 1% of the general Western population but has been reported to be more common among patients with breast and prostate cancer. The aim of this study was to investigate the significance of CHEK2*1100delC as a...

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Source

Identifiers

PMID: 16452051
DOI: 10.1080/00365590500368518

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.PMID 16452051Read ↗

CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.Semantic proximity Read ↗

CHEK2 variants associate with hereditary prostate cancer.Semantic proximity Read ↗

<i>CHEK2</i><b><sup>∗</sup></b>1100delC Mutation and Risk of Prostate CancerSemantic proximity Read ↗

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.Semantic proximity Read ↗

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.Semantic proximity Read ↗

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.Semantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

A novel founder CHEK2 mutation is associated with increased prostate cancer risk.Semantic proximity Read ↗

[CHEK2 c.1100delC may not contribute to genetic background of hereditary breast cancer from Shanghai of China].Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia.Semantic proximity Read ↗

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