Article
Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals.
BMC genetics - 30 Dec 2005
Lewinger Juan Pablo, Lee Sophia S F, Biernacka Joanna, Wu Long Yang, Shi Haijiang Steven, Bull Shelley B
Abstract excerpt
We use the Genetic Analysis Workshop 14 simulated data to explore the effectiveness of a two-stage strategy for mapping complex disease loci consisting of an initial genome scan with confidence interval construction for gene location, followed by fine mapping with family-based tests of association on a dense set of single-nucleotide polymorphisms. We considered four types of intervals: the 1-LOD interval, a basic...
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