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Article

RNase PH is essential for tRNA processing and viability in RNase-deficient Escherichia coli cells.

The Journal of biological chemistry - 15 Aug 1992

Kelly K O, Reuven N B, Li Z, Deutscher M P

Abstract excerpt

RNase PH is a Pi-dependent exoribonuclease that can act at the 3' terminus of tRNA precursors in vitro. To obtain information about the function of this enzyme in vivo, the Escherichia coli rph gene encoding RNase PH was interrupted with either a kanamycin resistance or a chloramphenicol resistance cassette and transferred to the chromosome of a variety of RNase-resistant strains. Inactivation of the chromosomal...

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PMID: 1644789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

RNase PH is essential for tRNA processing and viability in RNase-deficient Escherichia coli cells.PMID 1644789Read ↗

The rph-1-Encoded Truncated RNase PH Protein Inhibits RNase P Maturation of Pre-tRNAs with Short Leader Sequences in the Absence of RppH.Semantic proximity Read ↗

An essential function for the phosphate-dependent exoribonucleases RNase PH and polynucleotide phosphorylase.Semantic proximity Read ↗

RNase II regulates RNase PH and is essential for cell survival during starvation and stationary phase.Semantic proximity Read ↗

Two pathways for RNase E action in Escherichia coli in vivo and bypass of its essentiality in mutants defective for Rho-dependent transcription termination.Semantic proximity Read ↗

Role of precursor sequences in the ordered maturation of E. coli 23S ribosomal RNA.Semantic proximity Read ↗

Identification and characterization of growth suppressors of Escherichia coli strains lacking phosphorolytic ribonucleases.Semantic proximity Read ↗

RNase activity of polynucleotide phosphorylase is critical at low temperature in Escherichia coli and is complemented by RNase II.Semantic proximity Read ↗

Polyadenylation helps regulate functional tRNA levels in Escherichia coli.Semantic proximity Read ↗

Polynucleotide phosphorylase functions both as a 3' right-arrow 5' exonuclease and a poly(A) polymerase in Escherichia coli.Semantic proximity Read ↗

Selective cloning of genes encoding RNase H from Salmonella typhimurium, Saccharomyces cerevisiae and Escherichia coli rnh mutant.Semantic proximity Read ↗

Either bacteriophage T4 RNase H or Escherichia coli DNA polymerase I is essential for phage replication.Semantic proximity Read ↗

Correlation of activity with phenotypes of Escherichia coli partial function mutants of rnh, the gene encoding RNase H.Semantic proximity Read ↗

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