RNase PH is essential for tRNA processing and viability in RNase-deficient Escherichia coli cells.

Article

RNase PH is essential for tRNA processing and viability in RNase-deficient Escherichia coli cells.

The Journal of biological chemistry - 15 Aug 1992

Kelly K O, Reuven N B, Li Z, Deutscher M P

Abstract excerpt

RNase PH is a Pi-dependent exoribonuclease that can act at the 3' terminus of tRNA precursors in vitro. To obtain information about the function of this enzyme in vivo, the Escherichia coli rph gene encoding RNase PH was interrupted with either a kanamycin resistance or a chloramphenicol resistan...

Topics

Escherichia coli
Exoribonucleases
Kinetics
Mutagenesis, Insertional
Phenotype
Plasmids
RNA Precursors
RNA Processing, Post-Transcriptional
RNA, Transfer
RNA, Transfer, Tyr
Ribonucleases
beta-Galactosidase

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