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Article

Polyadenylation helps regulate functional tRNA levels in Escherichia coli.

Nucleic acids research - 1 May 2012

Mohanty Bijoy K, Maples Valerie F, Kushner Sidney R

Abstract excerpt

Here we demonstrate a new regulatory mechanism for tRNA processing in Escherichia coli whereby RNase T and RNase PH, the two primary 3' → 5' exonucleases involved in the final step of 3'-end maturation, compete with poly(A) polymerase I (PAP I) for tRNA precursors in wild-type cells. In the absence of both RNase T and RNase PH, there is a >30-fold increase of PAP I-dependent poly(A) tails that are ≤10 nt in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22287637
DOI: 10.1093/nar/gks006
PMCID: PMC3378859

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