Ethnicity affects the distribution of delta-aminolevulinic acid dehydratase (ALAD) genetic variants.

doi:10.1016/j.cca.2005.12.009

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Article

Ethnicity affects the distribution of delta-aminolevulinic acid dehydratase (ALAD) genetic variants.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2006

Montenegro Marcelo F, Barbosa Fernando, Sandrim Valeria C, Gerlach Raquel F, Tanus-Santos Jose E

Abstract excerpt

BACKGROUND: delta-Aminolevulinic acid dehydratase (ALAD) catalyzes the second step of heme synthesis. The ALAD gene shows a polymorphism (G-to-C transversion at position 177) leading to 2 alleles (ALAD1 and ALAD2) and 3 phenotypes (ALAD 1-1, ALAD 1-2 and ALAD 2-2). This polymorphism has been shown to affect lead toxicity and the risk of meningioma. In addition, there is little evidence showing interethnic...

Topics

Adolescent
Adult
Alleles
Brazil
Female
Genetic Variation
Genotype
Humans
Male
Middle Aged
Porphobilinogen Synthase

Source

Open in PubMed

Identifiers

PMID: 16445899
DOI: 10.1016/j.cca.2005.12.009

Genes

ALAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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